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Jinyuan Zhou , Ph.D.
Professor of Radiology & Oncology
Johns Hopkins University School of Medicine

RESEARCH INTERESTS

Dr. Zhou's research focuses on developing new in vivo MRI and MRS methodologies to study brain function and disease. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, high-resolution diffusion tensor imaging (DTI), magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, and tissue protein MR imaging. Notably, Dr. Zhou and his colleagues invented the amide proton transfer (APT) approach for brain pH imaging and tumor protein imaging. His initial paper on brain pH imaging was published in Nature Medicine in 2003 and his recent paper on tumor treatment effects was published in Nature Medicine in 2011. A major part of his current research is the pre-clinical and clinical imaging of brain tumors, stroke, traumatic brain injury, and other neurologic disorders using the APT and other novel MRI techniques. The overall goal is to achieve the MRI contrast at the protein and peptide level without injection of exogenous agents and improve the diagnostic capability of MRI and the patient outcome. In the past fifteen years, he has fullied a leading role for this important field in optimizing CEST or more specifically APT imaging technologies and in making them available for clinical examination.

ACTIVE PROJECTS 

NIH/NINDS R01NS083435
Title: US-China Collaborative Research on Stroke Imaging
The goal is to validate a novel comprehensive MRI exam protocol, including pH, diffusion, and perfusion imaging, for the assessment of ischemic stroke and recovery from stroke.
PI: Jinyuan Zhou
Period: 09/01/13 - 07/31/17

NIH/NCI R01CA166171
Title: Academic-Industrial Partnership to Develop Clinical Brain Cancer Imaging
The goal is to collaborate with Philips Healthcare to develop and optimize the APT-MRI hardware and software system on clinical 3T equipment.
PIs: Jinyuan Zhou, Peter van Zijl
Period: 02/05/13 - 01/31/18

NIH/NIBIB, R01EB009731
Title: Amide Proton Transfer (APT) MRI of Brain Tumors at 3T and 7T
The goal is to develop the new amide proton transfer (APT)-MRI methodology for more easy use in the clinic and to assess the capability and meaning of APT imaging for diagnosing heterogeneous aspects of gliomas.
PI: Jinyuan Zhou
Period: 07/01/09 - 11/30/18

NIH/NIBIB, R01EB015032
Title: Novel Approaches for CEST Labeling, Detection, Quantification and Translation
The goal is to develop quantitative MRI approaches and CEST agents for the drug delivery and gene expression in animals and humans.
PI: Peter van Zijl
Period: 08/01/11 - 06/30/20
Role: Co-Investigator

NIH/NIBIB, P41EB015909 (Previous NIH/NCRR, P41RR015241)
“Resource for Quantitative Functional MRI”
The major goal is to provide state-of-the-art MRI and MRS data acquisition and image processing technology and unique MR expertise to facilitate the biomedical research of NIH-funded neuroscientists at several institutions in Maryland and throughout the USA.
PI: Peter van Zijl
Period: 09/30/01 - 08/31/21
Role: Co-Investigator

 

SELECTED PEER-REVIEWED PUBLICATIONS

    1. Yi Zhang, Hye-Young Heo, Dong-Hoon Lee, Shanshan Jiang, Xuna Zhao, Paul Bottomley, Jinyuan Zhou. Chemical Exchange Saturation Transfer (CEST) Imaging with Fast Variably-accelerated Sensitivity Encoding (vSENSE). Magn. Reson. Med. DOI 10.1002/mrm.26307 (2016). NIHMS790434.
    2. Hye-Young Heo, Yi Zhang, Dong-Hoon Lee, Shanshan Jiang, Xuna Zhao, and Jinyuan Zhou. Accelerating Chemical Exchange Saturation Transfer (CEST) MRI by Combining Compressed Sensing and Sensitivity Encoding Techniques. Magn. Reson. Med. DOI: 10.1002/mrm.26141 (2016). NIHMS790160.
    3. Hye-Young Heo, Yi Zhang, Shanshan Jiang, Dong-Hoon Lee, and Jinyuan Zhou. Quantitative Assessment of Amide Proton Transfer (APT) and Nuclear Overhauser Enhancement (NOE) Imaging with Extrapolated Semi-solid Magnetization Transfer Reference (EMR) Signals: II. Comparison of Three EMR Models and Application to Human Brain Glioma at 3 T. Magn. Reson. Med. 75, 1630-1639 (2016). PMC4662920.
    4. Jinyuan Zhou, He Zhu, Michael Lim, Lindsay Blair, Alfredo Quinones-Hinojosa, Steven A. Messina, Charles Eberhart, Martin Pomper, John Laterra, Peter B. Barker, Peter C.M. van Zijl, and Jaishri Blakeley. Three-Dimensional Amide Proton Transfer MR Imaging of Gliomas: Initial Experience and Comparison with Gadolinium Enhancement. J. Magn. Reson. Imaging. 38, 1119-1128 (2013). PMC3664658.
    5. Jinyuan Zhou, Erik Tryggestad, Zhibo Wen, Bachchu Lal, Tingting Zhou, Rachel Grossman, Kun Yan, Silun Wang, De-Xue Fu, Jaishri Blakeley, Eric Ford, Betty Tyler, John Laterra, and Peter C.M. van Zijl. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature Med. 17, 130-134 (2011). PMC3058561.
    6. He Zhu, Craig K. Jones, Peter C. M. van Zijl, Peter B. Barker, and Jinyuan Zhou. Fast 3D Chemical Exchange Saturation Transfer (CEST) Imaging of the Human Brain. Magn. Reson. Med. 64, 638-644 (2010). PMC2932772.
    7. Jinyuan Zhou and Peter van Zijl. Chemical Exchange Saturation Transfer imaging and Spectroscopy. Progr. NMR Spectr. 48, 108-135 (2006).
    8. Jinyuan Zhou, David A. Wilson, Phillip Zhe Sun, Judith A. Klaus, and Peter C. M. van Zijl. Quantitative Description of Proton Exchange Processes between Water and Endogenous and Exogenous Agents for WEX, CEST, and APT Experiments. Magn. Reson. Med. 51, 945-952 (2004).
    9. Jinyuan Zhou, Bachchu Lal, David A. Wilson, John Laterra, and Peter C. M. van Zijl. Amide Proton Transfer (APT) Contrast for Imaging of Brain Tumors. Magn. Reson. Med. 50, 1120-1126 (2003).
    10. Jinyuan Zhou, Jean-Francois Payen, David A. Wilson, Richard J. Traystman, and P. C. M. van Zijl. Using the Amide Proton Signals of Intracellular Proteins and Peptides to Detect pH Effects in MRI. Nat. Med. 9, 1085-1090 (2003).

     

     

     

     

     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Contact Information:

Mailing: 600 N. Wolfe Street, Park 336, Baltimore, MD 21287
Phone: 410.955.7491
FAX: ....410.614.1977
email: jzhou@mri.jhu.edu

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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