Research Interests

 

 

 

 

Current research is aimed at the development of an integrated MRI exam of left ventricular mechanics from tissue tagged MRI and first-pass studies of myocardial perfusion from contrast-enhanced MRI. The goal of this research is to understand the underlying pathophysiology of myocardial infarction and to aid in the distinction of hibernating and stunned myocardium.

Additional research interests include the development of techniques to measure myocardial fiber architecture noninvasively with MRI using diffusion weighted imaging and the study of novel exogenous MR contrast agents to enhance the detection of myocardial ischemia. From the ability to determine myocardial fiber angles, the abilty to convert measurements of myocardial strain to stress could be envisioned. The interaction between myocardial contraction and blood flow could then be more clearly determined.

It is also a goal of the lab to aid in the development of animal models of human disease for noninvasive imaging studies.

 

 

Other Appointments:

Affiliations:

American Veterinary Medical Association
Institute of Electrical and Electronics Engineers
Society of Magnetic Resonance in Medicine

Publications:

1. Kraitchman DL , Wilke N, Hexeberg E, Jerosch-Herold M, Wang Y, Parrish T, Chang C-N, Zhang Y, Bache RJ, Axel L: Myocardial perfusion and function in dogs with moderate coronary stenosis. Magn Res Med, 1996, 35:771-780.
2. Kraitchman DL , Bloomgarden DC, Fayad ZA, Dougherty L, Blom AS, Wright F, Chang C-N, Young AA, Spear J, Moore EN, Axel L: Assessment of regional function and perfusion in canine myocardial infarction using MR tagging and first-pass contrast enha ncement. American Heart Association, Anaheim, November 1995.
3. Kraitchman DL , Young AA, Axel L: Semi-automatic tracking of myocardial motion in MR tagged images. IEEE-TMI, 1995 14{3}:422-433.
4. Young AA, Kraitchman DL , Dougherty L, Axel L: Tracking and finite element modeling of stripe deformation in magnetic resonance tagging. IEEE-TMI, 1995 14(3): 413-421.
5. Axel L, Bloomgarden D, Chang C-N, Kraitchman D , Young A: An integrated program for 2-D and 3-D analysis and display of heart wall motion from MRI. Computers in Cardiology, Vienna, Austria, September 1995.
6. Fayad ZA, Ferrari VA, Kraitchman DL , Bloomgarden DC, Axel L: Right ventricular wall mechanics with tagged MRI in normals and patients with right ventricular hypertrophy. Computers in Cardiology, Vienna, Austria, September 1995.
7. Kraitchman DL , Bloomgarden DC, Fayad ZA, Dougherty L, Blom AS, Wright F, Chang C-N, Young AA, Spear J, Axel L: Assessment of regional function in canine myocardial ischemic injury using MR tagging and first-pass contrast enhanced MR imaging. So ciety of Magnetic Resonance, 3rd Annual Scientific Meeting, Nice, France, August 1995.
8. Fayad ZA, Ferrari VA, Kraitchman DL , Bloomgarden DC, Foo TKF, Axel L: 2D right ventricular wall mechanics with tagged MRI in normals and patients with right ventricular hypertrophy. Society of Magnetic Resonance, 3rd Annual Scientific Meeting, Nice, France, August 1995.
9. Wilke N, Kraitchman D , Jerosch-Herold M, Hexeberg E, Parrish T, Ishibashi Y, Wang Y, Chang C-N, Axel L, Ugurbil K: Myocardial perfusion and strain assessed by magnetic resonance imaging. Circulation 1994 90(4):I-410.
10. Kraitchman D , Wilke N, Hexeberg E, Jerosch-Herold M, Parrish T, Chang C-N, BacheRJ, Axel L: Integrated comparison of myocardial perfusion and function in dogs with coronary stenosis. Society of Magnetic Resonance, 2nd Annual Scientific Meeting, San Francisco, August 1994.
11. Fayad ZA, Kraitchman DL , Ferrari VA, Axel L: Right ventricular regional function in normal subjects using magnetic resonance tissue tagging. Society of Magnetic Resonance 2nd Annual Scientific Meeting, San Francisco, August 1994.
12. Bloomgarden DC, Young AA, Kraitchman DL , Fayad ZA, Hunter PJ, Axel L: An integrated finite element model of left ventricular anatomy and function from magnetic resonance images of the intact canine heart. Second World Congress of Biomechanics A msterdam, July 1994.
13. Young AA, Kraitchman D , Axel L: Deformable models for tagged MR images: reconstruction of two- and three-dimensional heart wall motion. Computer Vision and Pattern Recognition Conference, Seattle, June 1994.
14. Axel L, Bloomgarden D, Chang C-N, Kraitchman D , Young A: Functional imaging of heart wall motion with tagged MRI. Society of Computed Body Tomography and Magnetic Resonance, Seventeenth Annual Course, April 1994.
15. Kraitchman D , Young AA, Axel L: Automated detection of stripes in tagged MR images. Investigative Radiology 1994; 28(12):1191.
16. Kramer C, Kraitchman D , Ferrari V, Axel L, Reichek N: Two-dimensional finite element analysis of longitudinal myocardial deformation and rigid body motion in hypertrophic cardiomyopathy. Scientific Conference on Application of Magnetic Resonanc e to the Cardiovascular System, American Heart Association, Councils on Clinical Cardiology, Cardiovascular Radiology, and Basic Science, December 1993.
17. Kraitchman D , Young AA, Axel L: Active contour models for tracking magnetic resonance tags. Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, October 29, 1993, 166-167.
18. Kraitchman D , Young AA, Axel L: Springs: A fast method for detection and correspondence of cardiac magnetic resonance tags. Society of Magnetic Resonance in Medicine, 12th Annual Scientific Meeting, New York, Book of Abstracts, August 14, 1993; 2:725.
19. Kramer C, Kraitchman D , Ferrari V, Chang, CN, Axel L, Reichek N: Two-dimensional finite element analysis of regional myocardial deformation and rigid body motion in hypertrophic cardiomyopathy. Circulation 1993; 88(4-2):I-345.
20. Fayad Z, Kraitchman D , Axel L: Magnetic resonance tagging: conventional spin-echo versus fast breath-hold gradient-echo imaging using phased-array coil. Society of Magnetic Resonance in Medicine, 12th Annual Scientific Meeting, New York, Book o f Abstracts, August 14, 1993; 2:1721.
21. Axel L, Bloomgarden D, Chang CN, Kraitchman D , Young AA, SPAMMVU: a program for the analysis of dynamic tagged MRI. Society of Magnetic Resonance in Medicine, 12th Annual Scientific Meeting, New York, Book of Abstracts, August 14, 1993; 2:724.
22. Axel L, Young, AA., Chang C-N, Fayad ZA, Kraitchman DL , Bloomgarden DC: Integrated approach to MRI cardiac function. IS&T/SPIE 1993 International Symposium on Electronic Imaging: Science & Technology, San Jose, 1992.
23. Axel L, Bloomgarden D, Chang CN, Goncalves R, Kraitchman D , Reichek N: MRI of normal regional heart wall motion, Society of Magnetic Resonance in Medicine, 10th Annual Scientific Meeting, San Francisco, Book of Abstracts, August 10, 1991; 1:13.

Contact Information:

Phone: 410.955.4892

FAX: 410.614.1977

email: dara@mri.jhu.edu